Estrogen, Efferent Ductules, and the Epididymis
نویسندگان
چکیده
منابع مشابه
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice.
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the efferent ductules and rete testis were primary targets of estrogen receptor function. In the present study, a more comprehensive evaluation of the ERKO male reproductive tract was performed to determin...
متن کاملDisruption of estrogen receptor signaling and similar pathways in the efferent ductules and initial segment of the epididymis
Seminiferous tubular atrophy may involve indirectly the disruption of estrogen receptor-α (ESR1) function in efferent ductules of the testis. ESR1 helps to maintain fluid resorption by the ductal epithelium and the inhibition or stimulation of this activity in rodent species will lead to fluid accumulation in the lumen. If not resolved, the abnormal buildup of fluid in the head of the epididymi...
متن کاملEffect of Coumestrol on Efferent Ductules in Dogs
The present study was conducted on twelve adult stray dogs of age 2 – 3 years, weighing 14 18 kg and randomly divided into three groups. Animals in group I (n = 5) and group II (n = 5) were orally given 300 and 500 microgram coumestrol dissolved in di-methyl sulfoxide in the commercial dog treats on days 0, 7, 14, 21 and 28, respectively. Animals in control group III (n = 2) were given DMSO alo...
متن کاملThe antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules
BACKGROUND The antiestrogen ICI 182,780 has been used successfully as an alternative experimental model for the study of estrogen action in the rodent adult male reproductive tract. Although ICI 182,780 causes severe alterations in testicular and efferent ductule morphology and function, the effects on the expression of estrogen and androgen receptors in the male have not been shown. METHODS ...
متن کاملAnalysis of Differential Expression of Cytochrome P450 Aromatase (Cyp19) in The Efferent Ductules and The Epididymis of Male Rats During Postnatal Development
요 약 본 연구는 생후 발달과정에서 숫 흰쥐의 생식기인 Efferent ductules (EDs)과 부정소에서 cytochrome P450 aromatase (Cyp19) 유전자의 발현과 연령별 발현 양상을 알아보는데 목적이 있다. 조직으로부터 추출된 total RNA는 역 전사 반응을 통해 cDNA로 바뀌어진 후 real-time PCR 기법을 사용하여 부위 별 그리고 연령별로 Cyp19 유전자 발현을 알아보았다. Cyp19 유전자의 발현은 EDs에서 90일령을 제 외한 7일, 14일, 그리고 30일령 등 성숙기 이전의 모든 연령에서 나타났으며, 부정소에서는 7일령을 제외한 모든 연령에서 보여졌다. 특히 부정소에서 Cyp19의 발현은 부정소의 각 부위별로 특이한 양 상을 보였다. 본 연구 결과를 통해...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2010
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.110.087353